ABSTRACT
The single-stranded RNA virus (coronavirus 2019) pandemic has represented a massive influence on health care professionals and communities around the world. This virus is accompanied by a range of respiratory disorders. Morbidity and mortality are in elevation among pregnant mothers. COVID-19 vaccine is considered safe for the majority of the population. Safety concerns were raised toward pregnant mothers and the COVID-19 vaccine. In the present study, data were taken out from relevant manuscripts; from 20th April 2021 to 25th December 2021. In this study, literature reviews from the most comprehensive health database on 100 papers published during 2020 and 2021 were used. This review article aimed to assess the present evidence available in the literature about the possible effect of COVID-19 on pregnant mothers and their fetuses and, to address considerations for maternal COVID-19 vaccine based on the review of existing data to aid in spreading the awareness about the benefits of vaccine that could save lives. In general, COVID-19 vaccines resulted in reducing the ability of virus transmission and patients' hospitalization. COVID-19 vaccines will never cause infection of corona virus. Evidence showed that COVID-19 vaccines from any brand will reduce the mortality and morbidity. However, available data indicated that possible deterioration of the clinical conditions of pregnant mothers infected with COVID-19 cannot be excluded. Primary outcomes did not show clear safety signs among pregnant mothers who received COVID-19 vaccines. This is because pregnant and lactating mothers were excluded from COVID-19 vaccine studies. Thus, data to lead vaccine decision-making are inadequate. More longitudinal follow up studies are necessary to reinforce the safety of the vaccine.